Cellular response to the genotoxic insult: the question of threshold for genotoxic carcinogens
نویسندگان
چکیده
منابع مشابه
Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens.
From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed. Analysis of the rate of the two steps by us and by others show that the first step-responsible for removal of the reactive epoxide from the system-works extraordinarily fast (typical...
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Based on the process of carcinogenesis, carcinogens are classified as either genotoxic or non-genotoxic. In contrast to non-genotoxic carcinogens, many genotoxic carcinogens have been reported to cause tumor in carcinogenic bioassays in animals. Thus evaluating the genotoxicity potential of chemicals is important to discriminate genotoxic from non-genotoxic carcinogens for health care and pharm...
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ژورنال
عنوان ژورنال: Toxicology Research
سال: 2015
ISSN: 2045-452X,2045-4538
DOI: 10.1039/c4tx00078a